ABSTRACT

A short half-life carbonic anhydrase Inhibitor such as Acetazolamide was developed as sustained release microcapsules to reduce the frequency of drug administration, ease of dose adjustment and improve patient compliance. The formulated sustained release microcapsules of Acetazolamide were prepared by solvent evaporation techniques using Ethyl cellulose and HPMC as polymer and particle size, encapsulation efficiencies and invitro releases of the fabricated microcapsules were evaluated. The final results showed that the encapsulation efficiencies were desired for all the formulations. Particle sizes of the microcapsules were influenced by the concentration of Ethyl cellulose and HPMC. From the results of the in vitro study shows that the desired release rate is achieved by the combination of Ethyl cellulose and HPMC.

Key words: Acetazolamide, Sustained release, Ethyl cellulose and HPMC.