It's commonly acknowledged that antioxidants may play a key role in treating male infertility and that oxidative stress is a major factor in the pathophysiology of male infertility. This study's primary goals are to, 1) thoroughly examine the available data about the effectiveness of antioxidants in treating male infertility, and 2) provide evidence-based clinical recommendations for the application of antioxidants in treating male infertility. A manual screening of papers accessible on Scopus was conducted as part of a systematic review of the clinical evidence that was available. The type of antioxidant employed, the clinical conditions being studied, the assessment of semen parameters, and the results of reproduction were among the data that were extracted. For every included study, the compliance with the JADAD score, the Cambridge Quality Checklist, the Cochrane Risk of Bias for randomized controlled trials (RCTs), and CONSORT criteria was examined. Furthermore, in order to assess the present and potential importance of antioxidants in male infertility, we offered a Strength Weakness Opportunity Threat (SWOT) study. Antioxidant supplementation improves semen parameters, as the current systematic research on antioxidants and male infertility clearly demonstrates. Furthermore, it offers the indications for antioxidant treatment in some clinical situations, such as changed semen quality, varicocele, and unexplained and idiopathic male infertility.

Keywords, Antioxidants, Oxidative stress, Practice guideline, Semen analysis, Sperm maturation